Positiva data för Cantargia - Life Science Sweden

Srsf10-medierad il1rap alternativ splicing reglerar

safety and tolerability trial of CAN04 a fully humanized monoclonal antibody against IL1RAP in subjects with solid malignant tumors. Målmolekylen för CAN04, IL1RAP, har påvisats på cancercellerna hos cirka 80 % av patienterna med urinblåsecancer. och cirka 80 % av patienterna hade IL1RAP-positiva cancerceller. Läs mer om: Cancer Cantargia. ”Vi vill rädda patienter med allvarliga cancer- och autoimmuna sjukdomar. Vi fokuserar I efterföljande forskning har Cantargia visat att IL1RAP även uttrycks på  ”Vi vill rädda patienter med allvarliga cancer- och autoimmuna sjukdomar. Bolaget har specialiserat sig på behandling riktad mot målmolekylen IL1RAP  Thereby, Cantargia has broadened its IP portfolio and secured ownership of the key patents around IL1RAP as a target for cancer therapy.

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Genetic variants in IL-1RAcP have been associated with prostate cancer,   16 Jun 2017 The program aims to develop an antibody that targets IL1RAP, against non- small-cell lung cancer (NSCLC) and pancreatic cancer, both as  10 Mar 2020 With IP purchase, Cantargia doubles down on IL1RAP target we have secured all relevant IP on IL1RAP as a target for cancer therapy.”. Somatic Cancer Mutations Germline IL1RAP Coreceptor for IL1RL2 in the IL- 36 signaling system. Coreceptor with IL1R1 Gene Symbols: IL1RAP. Molecular   Anti-IL1RAP antibody produced in rabbit (Anti-C3orf13 ); Prestige Antibodies The antibodies that have been generated in support of the Tissue and Cancer  18 Mar 2021 Under the deal, Boston Pharma will develop pre-phase 2 programs from GSK, starting with a monoclonal antibody targeting IL1RAP, a protein  5 Dec 2019 (IL1RAP). The lead project CAN04 is in phase IIa clinical development for the treatment of pancreatic cancer and non-small cell lung cancer. 18 May 2018 Researchers are currently developing ways to prompt a patient's own immune cells to selectively recognise and kill IL1RAP-expressing cancer  13 Nov 2019 IntroductionOne of the contributing factors to the relapse of acute myeloid leukemia (AML) is the presence of leukemia stem cells (LSCs). 8 Apr 2020 The antibody CAN04 binds IL1RAP with high affinity and its anti-tumor activity consists both of stimulation of immune cells to eradicate cancer  7 Feb 2019 The anti-IL1RAP antibodies provided herein are, inter alia, useful for the treatment of IL1RAP-expressing cancers such as AML. # -  7 Nov 2019 Background: Hepatocellular carcinoma (HCC) is one of the most prevalent tumors worldwide.

IL1RAP – Interleukin-1 Receptor Accessory Protein - IPOhub

Background: Interleukin 1 receptor Accessory protein, IL1RAP, is expressed in several solid tumors, both on cancer cells and tumor-associated inflammatory cells. CAN04 is a first-in-class fully humanized monoclonal antibody targeting IL1RAP blocking IL-1 alpha and beta signaling and triggering antibody dependent cellular cytotoxicity.

Positiva data för Cantargia - Life Science Sweden

2016 Jan;30(1):253-7. doi: 10.1038/leu.2015.135. Epub 2015 Jun 12. IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome. Secures all relevant IP on IL1RAP as a target for cancer therapy. Cantargia has a broad patent protection, including IP on the antibody CAN04 valid until 2035, and other IL1RAP binding antibodies. In addition, Cantargia also has patents on antibody therapy targeting IL1RAP in both solid tumors and in hematological cancer.

pancreatic cancer, non-small cell lung cancer (NSCLC), triple-negative breast Interleukin-1 (IL-1) receptor accessory protein (IL1RAP) is a co-receptor of the IL-1 receptor (IL1R1) and is required for IL-1 signaling. IL1RAP is overexpressed in various solid tumors (Figure 1), both on cancer cells and in the tumor microenvironment. CAN04 is a fully humanized antibody CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment. Expression of IL1RAP in cancer tissue.
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CAN04 is a fully humanized antibody that binds IL1RAP with high affinity (Kd = 1.10 pM), disrupts IL1α and IL1β signaling (IC50 = 3.9 and 4.1 nM respectively) and is glycoengineered to mediate an enhanced antibody-dependent cellular cytotoxicity (ADCC, EC50 < 1 nM). IL-1RAcP-null ( Il1rap knock-out) mice exhibit loss of IL-1 receptor mediated signal transduction. These mice may be useful in studying the role of IL-1 cytokine signaling in immune responses such as IL-33 receptor complexes and oncogenic signaling pathways ( e.g. , AML, CML). 2018-06-07 IL1RAP has not been detected as a mutational cancer driver IL1RAP reports Methods; Mutation distribution; Gene details IL1RAP Ensembl ID ENSG00000196083 Transcript ID ENST00000317757 Protein ID ENSP00000314807 Mutations IL1RAP Peptide Modified Sequence N[+1.0]TTYC[+57.0]SK Modification Type Deamidated (N), Carbamidomethyl (C) Protein - Site of Modification 118, 122 Peptide - Site of Modification 1, 5 Peptide Start 118 Peptide End 124 Figure 1. Schematic of data sources for My Cancer Genome.

Leukemia. 2016 Jan;30(1):253-7. doi: 10.1038/leu.2015.135. Epub 2015 Jun 12. IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome. Secures all relevant IP on IL1RAP as a target for cancer therapy. Cantargia has a broad patent protection, including IP on the antibody CAN04 valid until 2035, and other IL1RAP binding antibodies.
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Tyrosine kinase inhibitors (TKI) have significantly increased survival of patients with CML, and deep responders may consider stopping the treatment. However, more than 50% of patients relapse and restart TKI, subsequently suffering unknown toxicity 2018-02-12 · Thus, from the splicing regulation of SRSF10 on IL1RAP, our study revealed the function of mIL1RAP in CC and the interaction between AS and inflammatory pathways in cancer. SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis Oncogene . 2018 May;37(18):2394-2409.

CAN04 is a first-in-class fully humanized monoclonal antibody targeting IL1RAP, a co-receptor for the IL-1 receptor which is expressed on human cancer cells. CAN04 binds to IL1RAP with high affinity in a manner that blocks signal transduction from IL-1 and IL-33 into the cells. IL1RAP Peptide Modified Sequence N[+1.0]TTYC[+57.0]SK Modification Type Deamidated (N), Carbamidomethyl (C) Protein - Site of Modification 118, 122 Peptide - Site of Modification 1, 5 Peptide Start 118 Peptide End 124 Expression of IL1RAP in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. IL1RAP is overexpressed in various solid tumors, both on cancer cells and in the tumor microenvironment. CAN04 is a fully humanized antibody that binds IL1RAP with high affinity (Kd = 1.10 pM), disrupts IL1α and IL1β signaling (IC50 = 3.9 and 4.1 nM respectively) and is glycoengineered to mediate an enhanced antibody-dependent cellular cytotoxicity (ADCC, EC50 < 1 nM). IL-1RAcP-null ( Il1rap knock-out) mice exhibit loss of IL-1 receptor mediated signal transduction.
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Publikationer AgeCap, Centrum för åldrande och hälsa

14 May 2018 But whether leukemic stem cells require IL1RAP to survive and cells to selectively recognize and kill IL1RAP-expressing cancer cells, but  7 Jun 2018 The company is developing humanised, monoclonal antibody (CAN04) against IL1RAP, expecting to induce ADCC in the cancer cells. 30 Aug 2017 By blocking the intracellular signals from the IL1RAP target molecule, thereby impairing the cancer cells' ability to secrete tumor stimulating  19 Apr 2016 For colorectal cancer (CRC), a novel scoring system based on the a complex with IL-1 receptor accessory protein (encoded by IL1RAP). 6 Oct 2017 the molecular target IL1RAP, will be investigated in patients with cancer. in this trial are non-small cell lung cancer and pancreatic cancer.

Ett steg närmare ny behandling mot leukemi – Vetenskap och

In addition, Cantargia also has patents on antibody therapy targeting IL1RAP in both solid tumors and in hematological cancer. Besides the patents that Cantargia already owns, there is one additional patent on IL1RAP as target for antibody-based therapy in hematological cancer: US patent no. 8,715,619 from Cellerant, valid until 2029. CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor-Engineered T Cells Cancer Res . 2019 Feb 1;79(3):663-675.

NSCLC models performed in mice lacking a functional immune system. 2504.